• 05:20 DSM

  12:54 CHS
  6Hrs, 34m 1 Stop (ORD)
• DSMDes Moines Airport 05:20 - CHS 12:54 6h 34m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 05:20
  ORDChicago O'Hare International Airport 09:39
• ORDChicago O'Hare International Airport 06:52
  CHSCharleston Airport 12:54
• 6h 34m (2h 47m)
• 1 Stop ORD · Chicago 2h 47m
• American Airlines (AA 6389)Crj 700 Canadair Regional
  American Airlines (AA 3931)Embraer 170
• American Airlines (AA 6389)
• • M
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  • S

• 06:00 DSM

  13:21 CHS
  6Hrs, 21m 1 Stop (DCA)
• DSMDes Moines Airport 06:00 - CHS 13:21 6h 21m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:00
  DCAWashington Ronald Reagan National Airport 11:30
• DCAWashington Ronald Reagan National Airport 09:29
  CHSCharleston Airport 13:21
• 6h 21m (2h 01m)
• 1 Stop DCA · Washington 2h 01m
• American Airlines (AA 5098)Crj 700 Canadair Regional
  American Airlines (AA 5018)Canadair Regional
• American Airlines (AA 5098)
• • -
  • -
  • -
  • -
  • -
  • -
  • S

• 06:00 DSM

  13:27 CHS
  6Hrs, 27m 1 Stop (DCA)
• DSMDes Moines Airport 06:00 - CHS 13:27 6h 27m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:00
  DCAWashington Ronald Reagan National Airport 11:30
• DCAWashington Ronald Reagan National Airport 09:29
  CHSCharleston Airport 13:27
• 6h 27m (2h 01m)
• 1 Stop DCA · Washington 2h 01m
• American Airlines (AA 5098)Crj 700 Canadair Regional
  American Airlines (AA 4470)Embraer Emb 175
• American Airlines (AA 5098)
• • M
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  • T
  • F
  • -
  • -

• 06:00 DSM

  13:50 CHS
  6Hrs, 50m 1 Stop (DCA)
• DSMDes Moines Airport 06:00 - CHS 13:50 6h 50m 1 Stop (DCA) Washington
• DSMDes Moines Airport 06:00
  DCAWashington Ronald Reagan National Airport 11:53
• DCAWashington Ronald Reagan National Airport 09:29
  CHSCharleston Airport 13:50
• 6h 50m (2h 24m)
• 1 Stop DCA · Washington 2h 24m
• American Airlines (AA 5098)Crj 700 Canadair Regional
  American Airlines (AA 4749)Embraer Emb 175
• American Airlines (AA 5098)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 10:15 BNA

  07:40 STL
  5Hrs, 25m 1 Stop (CHS)
• BNANashville Airport 10:15 - STL 07:40 5h 25m 1 Stop (CHS) Charleston
• BNANashville Airport 10:15
  DSMDes Moines Airport 06:25
• CHSCharleston Airport 12:50
  STLSt Louis Lambert Intl Airport 07:40
• 5h 25m (1h 25m)
• 1 Stop CHS · Charleston 1h 25m
• Southwest Airlines (WN 1417)Boeing 737 800
  Southwest Airlines (WN 372)Boeing 737 700
• Southwest Airlines (WN 1417)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 06:55 DSM

  14:14 CHS
  6Hrs, 19m 1 Stop (CLT)
• DSMDes Moines Airport 06:55 - CHS 14:14 6h 19m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:55
  CLTCharlotte Airport 13:04
• CLTCharlotte Airport 10:12
  CHSCharleston Airport 14:14
• 6h 19m (2h 52m)
• 1 Stop CLT · Charlotte 2h 52m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 5313)Canadair Regional
• American Airlines (AA 2854)
• • M
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  • F
  • -
  • S

• 06:55 DSM

  12:16 CHS
  4Hrs, 21m 1 Stop (CLT)
• DSMDes Moines Airport 06:55 - CHS 12:16 4h 21m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 06:55
  CLTCharlotte Airport 11:05
• CLTCharlotte Airport 10:12
  CHSCharleston Airport 12:16
• 4h 21m (53m)
• 1 Stop CLT · Charlotte 53m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 3835)Embraer Emb 175
• American Airlines (AA 2854)
• • M
  • T
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  • T
  • F
  • -
  • S

• 07:35 DSM

  15:48 CHS
  7Hrs, 13m 1 Stop (CLT)
• DSMDes Moines Airport 07:35 - CHS 15:48 7h 13m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 07:35
  CLTCharlotte Airport 14:37
• CLTCharlotte Airport 10:52
  CHSCharleston Airport 15:48
• 7h 13m (3h 45m)
• 1 Stop CLT · Charlotte 3h 45m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 5169)Canadair Regional
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 07:35 DSM

  14:14 CHS
  5Hrs, 39m 1 Stop (CLT)
• DSMDes Moines Airport 07:35 - CHS 14:14 5h 39m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 07:35
  CLTCharlotte Airport 13:04
• CLTCharlotte Airport 10:52
  CHSCharleston Airport 14:14
• 5h 39m (2h 12m)
• 1 Stop CLT · Charlotte 2h 12m
• American Airlines (AA 2854)Airbus
  American Airlines (AA 5313)Canadair Regional
• American Airlines (AA 2854)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 08:00 DSM

  13:57 CHS
  4Hrs, 57m 1 Stop (ORD)
• DSMDes Moines Airport 08:00 - CHS 13:57 4h 57m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 08:00
  ORDChicago O'Hare International Airport 10:35
• ORDChicago O'Hare International Airport 09:27
  CHSCharleston Airport 13:57
• 4h 57m (1h 08m)
• 1 Stop ORD · Chicago 1h 08m
• United Airlines (UA 1363)Boeing 737 800
  United Airlines (UA 3517)Embraer 175
• United Airlines (UA 1363)
• • M
  • T
  • W
  • -
  • F
  • S
  • S

• 08:00 DSM

  13:57 CHS
  4Hrs, 57m 1 Stop (ORD)
• DSMDes Moines Airport 08:00 - CHS 13:57 4h 57m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 08:00
  ORDChicago O'Hare International Airport 10:35
• ORDChicago O'Hare International Airport 09:27
  CHSCharleston Airport 13:57
• 4h 57m (1h 08m)
• 1 Stop ORD · Chicago 1h 08m
• United Airlines (UA 1363)Boeing 737 800
  United Airlines (UA 3517)Embraer 170
• United Airlines (UA 1363)
• • -
  • -
  • -
  • T
  • -
  • -
  • -

• 08:00 DSM

  16:22 CHS
  7Hrs, 22m 1 Stop (IAH)
• DSMDes Moines Airport 08:00 - CHS 16:22 7h 22m 1 Stop (IAH) Houston
• DSMDes Moines Airport 08:00
  IAHHouston George Bush Intercontinental Airport 12:50
• IAHHouston George Bush Intercontinental Airport 10:40
  CHSCharleston Airport 16:22
• 7h 22m (2h 10m)
• 1 Stop IAH · Houston 2h 10m
• United Airlines (UA 5456)Embraer 175
  United Airlines (UA 6049)Embraer 175
• United Airlines (UA 5456)
• • M
  • T
  • -
  • T
  • F
  • S
  • S

• 11:29 DSM

  18:25 CHS
  5Hrs, 56m 1 Stop (DFW)
• DSMDes Moines Airport 11:29 - CHS 18:25 5h 56m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 11:29
  DFWDallas/Fort Worth Intl Airport 15:00
• DFWDallas/Fort Worth Intl Airport 13:45
  CHSCharleston Airport 18:25
• 5h 56m (1h 15m)
• 1 Stop DFW · Dallas 1h 15m
• American Airlines (AA 3743)Embraer Emb 175
  American Airlines (AA 1510)Boeing 737 800
• American Airlines (AA 3743)
• • M
  • -
  • -
  • -
  • -
  • -
  • -

• 11:29 DSM

  18:25 CHS
  5Hrs, 56m 1 Stop (DFW)
• DSMDes Moines Airport 11:29 - CHS 18:25 5h 56m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 11:29
  DFWDallas/Fort Worth Intl Airport 15:00
• DFWDallas/Fort Worth Intl Airport 13:38
  CHSCharleston Airport 18:25
• 5h 56m (1h 22m)
• 1 Stop DFW · Dallas 1h 22m
• American Airlines (AA 1286)Airbus
  American Airlines (AA 1510)Boeing 737 800
• American Airlines (AA 1286)
• • -
  • -
  • -
  • T
  • F
  • -
  • S

• 11:29 DSM

  20:25 CHS
  7Hrs, 56m 1 Stop (DFW)
• DSMDes Moines Airport 11:29 - CHS 20:25 7h 56m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 11:29
  DFWDallas/Fort Worth Intl Airport 17:00
• DFWDallas/Fort Worth Intl Airport 13:45
  CHSCharleston Airport 20:25
• 7h 56m (3h 15m)
• 1 Stop DFW · Dallas 3h 15m
• American Airlines (AA 3743)Embraer Emb 175
  American Airlines (AA 1422)Airbus
• American Airlines (AA 3743)
• • -
  • T
  • -
  • -
  • -
  • -
  • -

• 12:29 DSM

  18:59 CHS
  5Hrs, 30m 1 Stop (DCA)
• DSMDes Moines Airport 12:29 - CHS 18:59 5h 30m 1 Stop (DCA) Washington
• DSMDes Moines Airport 12:29
  DCAWashington Ronald Reagan National Airport 17:00
• DCAWashington Ronald Reagan National Airport 15:59
  CHSCharleston Airport 18:59
• 5h 30m (1h 01m)
• 1 Stop DCA · Washington 1h 01m
• American Airlines (AA 5388)Crj 700 Canadair Regional
  American Airlines (AA 4473)Embraer Emb 175
• American Airlines (AA 5388)
• • M
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  • T
  • -
  • -
  • S

• 13:59 DSM

  21:59 CHS
  7Hrs, 00m 1 Stop (CLT)
• DSMDes Moines Airport 13:59 - CHS 21:59 7h 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 13:59
  CLTCharlotte Airport 20:50
• CLTCharlotte Airport 17:14
  CHSCharleston Airport 21:59
• 7h (3h 36m)
• 1 Stop CLT · Charlotte 3h 36m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 2882)Airbus
• American Airlines (AA 2962)
• • -
  • -
  • W
  • -
  • -
  • -
  • -

• 13:59 DSM

  19:37 CHS
  4Hrs, 38m 1 Stop (CLT)
• DSMDes Moines Airport 13:59 - CHS 19:37 4h 38m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 13:59
  CLTCharlotte Airport 18:30
• CLTCharlotte Airport 17:14
  CHSCharleston Airport 19:37
• 4h 38m (1h 16m)
• 1 Stop CLT · Charlotte 1h 16m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 1586)Airbus
• American Airlines (AA 2962)
• • -
  • -
  • W
  • -
  • -
  • -
  • -

• 14:00 DSM

  21:59 CHS
  6Hrs, 59m 1 Stop (CLT)
• DSMDes Moines Airport 14:00 - CHS 21:59 6h 59m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 14:00
  CLTCharlotte Airport 20:50
• CLTCharlotte Airport 17:15
  CHSCharleston Airport 21:59
• 6h 59m (3h 35m)
• 1 Stop CLT · Charlotte 3h 35m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 2882)Airbus
• American Airlines (AA 2962)
• • M
  • T
  • -
  • T
  • F
  • -
  • S

• 14:00 DSM

  19:05 CHS
  4Hrs, 05m 1 Stop (CLT)
• DSMDes Moines Airport 14:00 - CHS 19:05 4h 05m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 14:00
  CLTCharlotte Airport 18:00
• CLTCharlotte Airport 17:15
  CHSCharleston Airport 19:05
• 4h 05m (45m)
• 1 Stop CLT · Charlotte 45m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 1586)Airbus
• American Airlines (AA 2962)
• • -
  • T
  • -
  • -
  • -
  • S
  • -

• 14:00 DSM

  19:39 CHS
  4Hrs, 39m 1 Stop (CLT)
• DSMDes Moines Airport 14:00 - CHS 19:39 4h 39m 1 Stop (CLT) Charlotte
• DSMDes Moines Airport 14:00
  CLTCharlotte Airport 18:30
• CLTCharlotte Airport 17:15
  CHSCharleston Airport 19:39
• 4h 39m (1h 15m)
• 1 Stop CLT · Charlotte 1h 15m
• American Airlines (AA 2962)Airbus
  American Airlines (AA 1586)Boeing 737 800
• American Airlines (AA 2962)
• • M
  • -
  • -
  • T
  • F
  • -
  • S

• 14:05 DSM

  21:25 CHS
  6Hrs, 20m 1 Stop (DEN)
• DSMDes Moines Airport 14:05 - CHS 21:25 6h 20m 1 Stop (DEN) Denver
• DSMDes Moines Airport 14:05
  DENDenver Intl Airport 16:15
• DENDenver Intl Airport 15:00
  CHSCharleston Airport 21:25
• 6h 20m (1h 15m)
• 1 Stop DEN · Denver 1h 15m
• Southwest Airlines (WN 2789)Boeing 737 Max 8 Passenger
  Southwest Airlines (WN 934)Boeing 737 800
• Southwest Airlines (WN 2789)
• • -
  • -
  • -
  • -
  • -
  • S
  • -

• 15:00 DSM

  22:22 CHS
  6Hrs, 22m 1 Stop (IAH)
• DSMDes Moines Airport 15:00 - CHS 22:22 6h 22m 1 Stop (IAH) Houston
• DSMDes Moines Airport 15:00
  IAHHouston George Bush Intercontinental Airport 18:48
• IAHHouston George Bush Intercontinental Airport 17:35
  CHSCharleston Airport 22:22
• 6h 22m (1h 13m)
• 1 Stop IAH · Houston 1h 13m
• United Airlines (UA 6033)Embraer 175
  United Airlines (UA 6048)Embraer 175
• United Airlines (UA 6033)
• • M
  • T
  • W
  • T
  • F
  • S
  • S

• 15:20 DSM

  21:36 CHS
  5Hrs, 16m 1 Stop (ORD)
• DSMDes Moines Airport 15:20 - CHS 21:36 5h 16m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 15:20
  ORDChicago O'Hare International Airport 18:15
• ORDChicago O'Hare International Airport 16:51
  CHSCharleston Airport 21:36
• 5h 16m (1h 24m)
• 1 Stop ORD · Chicago 1h 24m
• United Airlines (UA 3457)Embraer 175
  United Airlines (UA 2075)Airbus
• United Airlines (UA 3457)
• • -
  • -
  • -
  • -
  • -
  • -
  • S

• 15:20 DSM

  21:36 CHS
  5Hrs, 16m 1 Stop (ORD)
• DSMDes Moines Airport 15:20 - CHS 21:36 5h 16m 1 Stop (ORD) Chicago
• DSMDes Moines Airport 15:20
  ORDChicago O'Hare International Airport 18:15
• ORDChicago O'Hare International Airport 16:48
  CHSCharleston Airport 21:36
• 5h 16m (1h 27m)
• 1 Stop ORD · Chicago 1h 27m
• United Airlines (UA 1568)Airbus
  United Airlines (UA 2075)Airbus
• United Airlines (UA 1568)
• • M
  • T
  • W
  • T
  • F
  • S
  • -

• 15:30 DSM

  22:16 CHS
  5Hrs, 46m 1 Stop (DFW)
• DSMDes Moines Airport 15:30 - CHS 22:16 5h 46m 1 Stop (DFW) Dallas
• DSMDes Moines Airport 15:30
  DFWDallas/Fort Worth Intl Airport 18:50
• DFWDallas/Fort Worth Intl Airport 17:42
  CHSCharleston Airport 22:16
• 5h 46m (1h 08m)
• 1 Stop DFW · Dallas 1h 08m
• American Airlines (AA 4001)Embraer Emb 175
  American Airlines (AA 1422)Airbus
• American Airlines (AA 4001)
• • M
  • -
  • -
  • T
  • F
  • S
  • S